Onderzoek
Onderzoek is een belangrijk onderdeel van het fonds. Vanuit de historie richtte Tekke Huizinga samen met Professor Kolff de eerste bloedbank van het Academisch Ziekenhuis op. Huizinga en Kolff waren echte pioniers op hun werkgebied.
Deze pioniersgedachte ligt ook ten grondslag aan de doelstellingen van het Tekke Huizinga Fonds, een bijdrage leveren aan vernieuwende ideeën of een eerste verkennende uitwerking daarvan binnen de aangegeven werkgebieden hematologie, transfusiegeneeskunde of gelieerde onderzoeksgebieden.
Sinds 2004 zijn meer dan twintig onderzoeksprojecten gehonoreerd, die waren aangevraagd door onderzoekers van Sanquin, UMCG en MST (Medisch Spectrum Twente). De onderstaande onderzoeken geven een beeld van de onderzoeksgebieden die voor een bijdrage in aanmerking kwamen.
Lipidomic and proteomic analysis of potentially transplantable lungs undergoing ex vivo lung perfusion (EVLP)
Dr. Ing. R. Hoffmann
Jaar: 2018
3DA treatment as a possible enhancer of hematopoietic stem cell function.
Ms. S. Buisman, BSc
Jaar: 2018
Hematopoietic stem cell transplantation is established as a treatment for a broad range of hematological diseases. However, suboptimal engraftment levels and low availability of hematopoietic stem cells (HSCs) limit the use. This highlights the importance of finding ways to maintain and expand the available HSCs and enhance their engraftment potential. In this project we test 3-DEAZAADENOSINE (3DA) as a candidate drug for preventing/blunting senescence. Preliminary in vitro data showed that 3DA treated cord blood CD34+ cells maintained more primitive. The Tekke Huizinga grant enabled us to further investigate whether in vitro 3DA treatment is able to enhance in vivo human HSC capacity.
Resuscitation of discarded donor human hearts on subnormothermic ex-situ machine perfusion with an acellular perfusate
Mr. V. van Suylen
Jaar: 2018
Clinical validation of the analysis of Everolimus, Sirolimus, and Mycophenolate Mofetil in Dried Blood Spots
Prof.dr. D. Touw
Jaar: 2017
Towards rational hemostatic management of critically ill patients with liver disease
Prof.dr. J.A. Lisman
Jaar: 2017
Liver disease is associated with complex changes in the hemostatic system. Although routine indices of hemostasis such as the platelet count and prothrombin time suggest a bleeding tendency, these patients are in fact in hemostatic balance due to a simultaneous decline in pro- and anticoagulant drivers. Whether this rebalanced hemostatic state remains when patients with liver disease become critically ill is unknown and subject of this proposal. Knowledge on the hemostatic status of critically ill patients with liver disease is vital for a rational approach to hemostatic management.
Is poor stem cell mobilization related to the emergence of clonal haematopoiesis in the bone marrow compartment?
Ms. I. van Zeventer, BSc, BA
Jaar: 2017
Some patients fail to mobilize sufficient numbers of CD34+ peripheral blood stem cells upon mobilization procedures for autologous hematopoietic cell transplantation. It is now known that clonal haematopoiesis might emerge during ageing and following chemotherapeutic treatment, implying a risk for development of myeloid neoplasms. We aim to study the presence of clonal haematopoiesis in poor mobilizers by a targeted sequencing approach and to relate the mutational profile to clinical outcomes and development of secondary haematological malignancies. Results from this study may contribute to improved and personalized treatment protocols.
Brain death and ischemia cause inflammatory and mitochondrial injury to donor lungs
Dr. M.E. Erasmus
Jaar: 2016
In our project we stabilized the damaging process by giving stem cells during ex situ perfusion and ventilation of rat donor lungs pre-transplant. Multiple smaller doses were most efficient.
Adult stem cells of the human thyroid gland; expansion and functionality
Prof.dr. R.P. Coppes
Jaar: 2016
Dissecting the epigenetic events that contribute to hematopoietic stem cell expansion
Ms. K. Mattes
Jaar: 2016
Leukemia stem cells play a crucial role in disease initiation and progression of acute myeloid leukemia (AML). We identified that altered expression of the transcriptional regulators CITED2 and PU.1 impacts the survival and maintenance of both normal- and leukemia stem cells. With support of “Tekke Huizingafonds” we investigated potential molecular mechanisms underlying this observation. Understanding the mechanisms that regulate stem cell self-renewal and survival can help to improve current protocols for hematopoietic stem cell transplantation or highlight opportunities for AML therapy.
Hibernation as key to unlock platelet cold storage
Mr. E.L. de Vrij
Jaar: 2016
The hemostatic status of critically ill patients with liver disease
Prof.dr. J.A. Lisman
Jaar: 2015
Towards ex vivo normothermic machine perfusion of human donor livers without the requirement for human blood products
Ms. A. Matton
Jaar: 2015
Multipotent donor lung therapy with mesenchymal stem cells in an ex vivo lung perfusion model using lungs from brain dead donorrats
Dr. M.E. Erasmus – UMCG
Jaar: 2013
Understanding erythropoiesis from (expanded) hematopoietic stem cells through modulation of CITED2
Dr. H. Schepers – UMCG
Jaar: 2013
With this proposal we will investigate the cellular and molecular mechanisms that the transcriptional regulator CITED2 uses in order to expand HSC numbers. We will furthermore gain a deeper understanding how CITED2 increases the overall erythroid output from these cells.
Organ preservation with hydrogensulfide in renal transplantation
Prof. dr. H. van Goor – UMCG
Jaar: 2013
Waterstof sulfide is protectief bij ischemische schade en kan bovendien cellen en weefsels in een hypometabole staat brengen. Dit concept gebruiken wij in het huidige project om organen te beschermen in de fase voorafgaand aan transplantatie.
Dissecting the architecture of the normal and leukemic ‘stem cell niche’
Drs. C.L.E. Hazenberg – UMCG
Jaar: 2012
In this research proposal, we study the changes in the bone marrow microenvironment of patients after autologous stem cell transplantation. By understanding the changes in the cellular compartments and the molecular pathways involved, we aim to improve future transplantation strategies and post-transplantational care, in order to improve patients’ outcomes.
Efficacy of pro- and antihemostatic drugs in plasma from patients with liver disease
Prof. dr. J.A. Lisman – UMCG
Jaar: 2012
This study has shown tremendous alterations in the anticoagulant effect of widely used drugs in plasma from patients with cirrhosis as compared to individuals with intact liver function (PLoS One. 2014 Feb 4;9(2):e88390). Our data may have important implications for dosing anticoagulant drugs in patients with cirrhosis.
Pilotstudie ‘normotherme machinepreservatie van humane donorlevers’
Dr. S. op den Dries – UMCG
Jaar: 2012
A prospective cohort piloty study for use of cryolijm-sq in patients with severe COPD
Dr. M. Tiekstra-Dijkstra – UMCG
Jaar: 2012
Detection of ischemia/reperfusion injury in human tissue: Anti-aggregatory and anti-inflammatory ectoenzymes in vascular endothelium.
Dr. F. Spaans – UMCG
Jaar: 2012
Bone marrow derived endothelial progenitor cell transplantation to ameliorate radiation-induced vascular remodelling in the lung
Prof. dr. R.P. Coppes – UMCG
Jaar: 2011
Exploiting possibilities to improve the long-term engrafment of the hematopoietic stem cell compartment following autologous stem cell transplantation
Dr. E. Vellenga- UMCG
Jaar: 2010
Transfusion policy in patients with complex changes of hemostatis – a rebalanced hemostatic status in patients with acute liver failure
Prof. Dr. J.A. Lisman – UMCG
Jaar: 2010
Transfusion as supportive care, study for improvement of quality of life
Dr. J. Slomp – MST, Enschede
Jaar: 2009
Will reinfusion of autologous stem cell products, independent of the composition of the transplant, directly in the bone marrow compartment improve steady state hematopoiesis post-transplantation?
Prof. Dr. E. Vellenga – UMCG
Jaar: 2008
The PLATO study disfunctionerende plaatjes bij lever transplantaties en preserverende werking van aprotinine
Prof. Dr. R.J. Porte – UMCG
Jaar: 2007
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